2-[(4-Acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide
IQ 1
CAS: 331001-62-8
Molecular Formula: C21H22N4O2
2-[(4-Acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide - Names and Identifiers
2-[(4-Acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide - Physico-chemical Properties
| Molecular Formula | C21H22N4O2 |
| Molar Mass | 362.42 |
| Appearance | powder |
| Color | yellow to orange |
| Storage Condition | -20°C |
| In vivo study | Treatment with IQ1 reduced the size of the lungs of the mouse embryo as well as the number of its branches. Despite inhibition of the distal branches of the lung, IQ1 elongated its proximal airway in E14.5 mouse embryos, suggesting that IQ1 is not just a growth inhibition. The treatment of IQ1 was carried out from E9.9, and the treatment was continued for 3 days, and IQ1 inhibited the branching. IQ1 leads to airway dilation, reduced mesenchymal cell density, and can also affect the development of the cardiovascular system. Its treatment resulted in a decrease in distal gene expression and an increase in proximal gene expression in lung transplant tissue. |
2-[(4-Acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.759 ml | 13.796 ml | 27.592 ml |
| 5 mM | 0.552 ml | 2.759 ml | 5.518 ml |
| 10 mM | 0.276 ml | 1.38 ml | 2.759 ml |
| 5 mM | 0.055 ml | 0.276 ml | 0.552 ml |
Last Update：2024-01-02 23:10:35
2-[(4-Acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide - Reference Information
| biological activity | IQ-1 can make mouse embryonic stem cells expand and prevent their non-directional differentiation driven by Wnt/β-catenin signal. In Wnt3a treated cells, the pluripotency of embryonic stem cells (ESC) is maintained and the interaction of PP2A/Nkd is prevented. |
| target | TargetValue β-catenin/p300 () |
| Target | Value |
| In vivo study | The treatment of IQ1 reduced the size of the lungs of the mouse embryo and the number of branches. Despite the inhibition of the distal branches of the lung, IQ1 elongated its proximal airway in E14.5 mouse embryos, suggesting that IQ1 was not just growth inhibition. The treatment of IQ1 was started from E9.9, and the treatment was continuous for 3 days, and IQ1 inhibited the branching. IQ1 can cause airway expansion, decrease of mesenchymal cell density, and also affect the development of cardiovascular system. Its treatment caused a decrease in distal gene expression and an increase in proximal gene expression in lung transplant tissues. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: IQ 1 Visit Supplier Webpage Request for quotationCAS: 331001-62-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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